2/28/2023 0 Comments Newly hired ndp doh region xPurpose: Transgender adults are highly stigmatized members of society. Lee, PharmD, MAS, APh, FCCP, BCPP 1,2ġ UC San Diego Health, San Diego, CA 2 UCSD Skaggs School of Pharmacy and Pharmaceutical Sciences, La Jolla, CA Future research in this area can seek to develop a standardized approach for antidepressant-associated QTc prolongation in patients.Īntidepressant Prescribing Patterns in Transgender Individuals Diagnosed With Gender Dysphoria and Mood or Anxiety DisordersĬasey M. The Mayo risk scoring tool was the most conservative while Tisdale was the least conservative. Conclusions: Available case reports demonstrate a lack of consistency regarding QT correction formula used, risk evaluation techniques, and clinical management strategies. The most common intervention was to stop the antidepressant (45%, 5/11). Only one case specified the QT correction formula utilized. For the remaining 7/11 (64%) cases the Tisdale and RISQ-PATH scores identified risk as “low” whereas the Mayo score identified risk as “high”. The three risk scoring tools agreed in 4/11 (36%) cases. The average patient was a 53.5-year-old female taking an SSRI with baseline and maximum QTc measurements of 420 msec and 535 msec, respectively. Results: A total of 11 case reports met criteria for inclusion. Mayo, Tisdale, and RISQ-PATH tools were used to calculate risk scores. Bazett, Fridericia, Framingham, and Hodges formulas were used to calculate QTc. Articles describing patients with antidepressant overdose or omitting a diagnosis of depression, baseline QTc measurement, or maximum QTc measurement were excluded except in the event of sudden cardiac death outside the hospital setting. Reports published between January 2000 and March 2021 were eligible for inclusion. Methods: A structured literature search was conducted to identify case reports describing QTc prolongation or TdP in individuals taking an antidepressant. Objectives: This review investigates documented cases of antidepressant-associated QTc prolongation and TdP to understand clinical decision-making in these patients. Currently, there is no consensus guidance on QTc calculation, risk assessment, or post-incident management for such cases. Background: Individuals with depression are at an increased risk of cardiovascular disease, which may be further complicated by antidepressant-associated QTc prolongation and Torsades de Pointe (TdP). Practical Approaches to Antidepressant-Associated QTc Prolongation: A Review of Casesīrittany Weger, PharmD Candidate Ali Goforth, PharmD Candidate Alexandra Cunha, PharmD Candidate Shaina Schwartz, PharmD, BCPP Julie Cooper, PharmD, BCPS, BCCP
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